溴苯那敏是第一代抗组胺药。

Brompheniramine is the first-generation antihistamines.

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第一种方法：用液溴作芳化试剂，将4-氯代四氢苯酐芳化为4-氯代苯酐，收率达到89%，纯度大于99%；

The first route was using the liquid bromine to aromatize the 4-chlorotetrahydrophthalic anhydride to 4-chlorophthalic anhydride, The yield was 89%, and the purity was more than 99%.

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