The responsibilities weigh heavily on him.

他肩负重任，寝食不安。

《牛津词典》

The French may believe their model is failing; the crisis, debt, unemployment weigh heavily on them.

法国人也许相信他们的榜样已经沦落；危机、债务、失业是他们承重的负担。

youdao

Various factors will weigh heavily on China's eventual entry into the World Trade Organization (WTO).

许多因素对中国最终加入世界贸易组织(WTO)有很大的影响。

youdao

Secretary Gates has indicated that casualties weigh heavily on him, along with the strategic importance of these decisions.

VOA: standard.2009.09.22

Further, a number of risks continue to weigh heavily on global growth as outlined above.

WHITEHOUSE: The Los Cabos Growth and Jobs Action Plan

The general cited a gap in existing defense capabilities that weigh heavily on a nuclear response.

CENTERFORSECURITYPOLICY: STRATCOM: Safe, reliable deterrence critical

Rather, it is a critical question whose answer will weigh heavily on the future of our great country.

FORBES: After Bush Tax Cuts, Payments By Wealthy Actually Increased