Objective To study the effects of hyperoxia on ventilator-induced lung injury(VILI) and the protection of dexamethasone.

目的观察高浓度氧对通气机所致肺损伤的影响，以及地塞米松的防护作用。

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Objective to establish an experimental model of ventilator-induced lung injury (VILI) in rats through tracheal tube and evaluate the influence of different ventilatory volumes on VILI in rat lung.

目的通过建立过度通气导致呼吸机相关性肺损伤(VILI)大鼠模型，评估不同潮气量对肺损伤的影响。

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Conclusion Low tidal volume ventilation can decrease cytokine release and can alleviate ventilator - induced lung injury (VILI) in animal models of ARDS.

结论低潮气量通气治疗ARDS动物模型能够减轻炎症诱发细胞因子的释放，减轻机械通气相关性肺损伤。

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