...屏障功能与免疫功能障碍导致肠道细菌移位和内毒素入血,并引发复杂的细胞因子级联反应,由此于20世纪90年代提出了二次打击(two-hit)的概念〔1〕。在失血性休克引起机体第一次打击后,常继发肠道细菌移位,脂多糖(LPS)是肠道细菌内
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...色体易位和13号染色体缺失是MGUS发生的原发事件，如在此基础上出现新的基因异常则为MGUS进展为MM的主要因素，即双次打击(two-hit)学说。二次打击是一个随机事件，而不是累积的损害
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总的说来，肿瘤抑制基因阻止肿瘤的发生，根据Knudson的双击（two-hit）假说，TSGs的功能丧失需要两个等位基因失活，突变、甲基化或其他改变作用在某个肿瘤抑制基因上，造成的一个等位基因的失活，而由...
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two-hit theory 二次突变假说 ; 次打击学说
two-hit hypothesis 二次突变假说
two-hit model 次打击模型
two base hit 二垒打 ; 二垒安打
Two Hit Ko 二击杀
Two hit rate 双命中率
two-hit multitarget 二击多靶
·2,447,543篇论文数据，部分数据来源于NoteExpress
While the two-hit hypothesis is useful conceptually, making predictions for particular individuals is still a challenge.
虽然这“两步假设法”理论上行得通，可是要预测特定个体，依然是一个挑战。
He also likes what he calls a "two-hit technique," where he starts a conversation, excuses himself, and then returns later to the same person.
他也喜欢用他所说的“两面夹攻的方法”，首先他先开始一段谈话，然后离开，再然后回来和之前的那个人继续交谈。
He hit him with two sharp lefts.
他给了他两记猛烈的左手拳。
In sub-Saharan Africa, the area hardest hit by AIDS, for every person who gets treated, two others go untreated.
VOA: special.2011.05.18
He hit two free throws in the final seconds to give Los Angeles an eighty-three to seventy-nine victory.
VOA: special.2010.06.25
It was a hit song performed by Celia Cruz and her band, La Sonora Matancera, in nineteen fifty-two.
VOA: special.2009.04.19
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