In mammalian cells, there are three transmembrane proteins locating on ER, that are Activating transcription factor-6(ATF6), Inositol requiring-1(IRE1)和PER-like ER kinase(PERK), they induce UPR by different signal transduction.
在哺乳动物细胞中,三个位于内质网的跨膜蛋白:ATF6(Activating transcription factor-6), IRE1(Inositol requiring-1)和PERK(PER-like ER kinase)通过不同的信号途径诱导UPR。
参考来源 - 胆固醇诱导的未折叠蛋白反应及其调节acat2基因表达的探讨·2,447,543篇论文数据,部分数据来源于NoteExpress
Structures prediction of TVBMV proteins using bioinformatics software showed that 6k2 and P3 were transmembrane proteins while others were not.
利用生物信息学软件对TVBMV编码蛋白的结构进行了预测,结果表明6k2和P3蛋白为跨膜蛋白。
So, that is just a quick example for some of you, you might be very familiar with ion channels, others might not know what these are, so I'll just tell you quite briefly that ion channels are these very massive transmembrane proteins.
这对你们中的某些人来说仅仅是个小例子,有些人可能已经非常熟悉离子通道这个概念了,但有些人可能还不清楚,那么就让我来简单地介绍一下离子通道,就是这些巨大的跨膜蛋白。
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