The EPA calls the toxicityofrotenonetowildlifeandhumans "low" and says no poisoningofbirdsormammalswouldresult from concentrations recommendedfor wiping out Asiancarp.
Much of that increase has been in a herbicide called glyphosate (the active ingredient in Roundup and generic versions of it) and because glyphosate has negligible toxicitytobirds, invertebrates and mammals, it has a much lower Environmental Impact Quotient (EIQ) than the herbicides it replaces.
In 1972, on the basis of data on toxicityto fish and migrating birds (but not to humans), the U.S. Environmental Protection Agency banned virtually all uses of DDT.