This has profoundly affected my life.

这已极大地影响了我的生活。

《柯林斯英汉双解大词典》

This is the proudest moment of my life.

这是我生命中最荣耀的时刻。

《牛津词典》

If this could be fulfilled, my life would be free of care.

如果这能实现，我的生活就无忧无虑了。

youdao

During my life on the range I'd seen plenty of prairie whirlwinds but this thing didn't move;

VOA: special.2009.12.07

This is actually something very near and dear to my heart because I literally would not be doing what I do in life today had I not taken a couple of courses here, this one in particular, pass fail.

事实上，我是很关心的,因为今天我就不会站在这里,如果当初我没有这里上课的话，这门课，要么过要么挂科。

哈佛公开课 - 计算机科学课程节选

You don't have to worry about getting tested on this material, at least not on my life story.

无需担心我会考你们这些,最起码不会考你们我的人生故事。

麻省理工公开课 - 固态化学导论课程节选

If I was a real snob, why would I be doing this with my life?

CNN: She ate 162 school lunches -- and blogged it

Nora Ephron made her directorial debut with the 1992 comedy, "This Is My Life, " which she co-wrote with her sister, Delia.

CNN: Nora Ephron, prolific writer and filmmaker, dies at age 71

"It's an absolute dream come true, I've dreamed about this all my life, " said McDowell, who won his fifth European Tour title in Wales two weeks ago.

BBC: US Open: Graeme McDowell triumphs at Pebble Beach