Resistance to earlier generation antimalarial medicines such as chloroquine and sulfadoxine-pyrimethamine is widespread in most malaria-endemic countries.
在大多数疟疾流行国家，对氯喹和磺胺多辛+乙胺嘧啶等较早一代抗疟药物的耐药性十分普遍。
After limited success, the disease rebounded in many places, due in part to the emergence of parasites that resisted drugs such as chloroquine that had previously held the malady at bay.
虽然取得了一定的成效，但疟疾在很多地方又卷土重来，部分原因就是出现了具有抗药性的疟原虫，比如抵抗传统疟疾治疗药物氯喹的疟原虫。
Chloroquine and antifolate drugs such as the sulphadoxine-pyrimethamine combination are safe and are still used in some regions because of their low cost.
Chloroquine和抗叶酸药物如sulphadoxine - pyrimethamine组合药物是安全的，而且仍在某些区域被使用，因为它们的价钱低。
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