Chief Executive StanleyCrookeStanley Crooke, 60, headed drug development at Smithkline Beckman and anti-cancer research at Bristol-Myers Squibb.

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Isis was founded in 1989 by Stanley Crooke, the former head of research at SmithKline Beckman, after he saw a technology called antisense that could block genes directly.

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Chief Executive Stanley Crooke , 60, headed drug development at Smithkline Beckman and anti-cancer research at Bristol-Myers Squibb (nyse: BMY - news - people ).

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