This thesis also runs into significant difficulties.

这个论题同样遇到了很大的问题。

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Individuals with severe social dysfunction can experience significant difficulties with everyday functioning.

严重社会机能障碍的人在日常处理中有明显困难。

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In practice, the existence of different types of seismic noises causes significant difficulties to reliably estimate intercept and gradient.

在实际应用中，不同类型地震噪声的存在给截距和梯度的可靠估计带来了很大困难。

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For a while orders were processed through DeArthur's showroom and mail-order business without significant difficulties.

FORBES: Magazine Article

Formula 1 teams, a majority of them British-based, and international media have faced significant difficulties in returning from China after Sunday's grand prix in Shanghai.

BBC: Volcanic ash cloud forces postponement of Japan MotoGP

Mr. Srivastava said apart from production issues, there are also significant difficulties in moving coal from mines to power stations due to a shortage of rail wagons for hauling the dry fuel.

WSJ: Coal to Keep Firing India Power Plants