When FitzGerald's group was uncovering the early-warning sign of dangers to come, Samuelsson's research group was laboring away on putting a new leaf on one of the branches of the prostaglandin tree. A postdoctoral fellow in the lab, Per-Johan Jakobsson, led a project that discovered the human version of an enzyme that produces PGE2. The abstract of a 1999 paper co-authored by Jakobsson, Samuelsson and two collaborators ends on an upbeat note, saying that the enzyme “is a potential novel target for drug development.”

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