Sadness and pain.

悲伤和痛苦。

youdao

The moving drama made me sense sadness and pain once again.

这个令人感动的戏剧让我再次感到悲伤和痛苦。

youdao

I feel a lot of stress and sadness and pain, because I want to help her.

我感到了很大的压力、悲伤还有痛苦，因为我想要帮助她。

youdao

In your pain and sadness, you may decide that the person you loved is hard-hearted, and in fact,has a heart of stone.

VOA: special.2010.07.18

Are personal sufferings, sadness and pain responsible for the output of creative people like artists and musicians?

FORBES: Should Creatives Be Paid Poorly?

She'd come out of surgery the day before, screaming all night, but we were used to that in one another and could sleep through noises of pain and sadness, or talk through them, about movies and boyfriends and sex and God, back and forth across the beds.

NPR: Excerpt: 'Warm Springs'

But who are these heartland Americans who are unable to feel pain and sadness?

ECONOMIST: The secret of happiness