There is a profound difference between math and Chinese.

数学和语文之间有着深刻的差异。

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A more profound difference has to do with how the problem is diagnosed.

然而两派更深的分歧却与对环境问题产生根源的看法不同有关。

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While this may seem like mincing words, there is in fact a profound difference.

虽然这点不同看起来像咬文嚼字，但实际上存在着深奥的区别。

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And I think that is a profound difference between his vision and the Republican vision.

WHITEHOUSE: Press Briefing by Press Secretary Jay Carney,

Today, a new element of leadership is making a profound difference in gauging business performance: corporate social responsibility.

FORBES: The Five Elements of the Best CSR Programs

At least in part, that fact is attributable to a profound difference between the parties: Governing is an avocation for Democratic partisans.

CENTERFORSECURITYPOLICY: Divided loyalties