对于研究基因变异对人体药物代谢的影响而言，使用安全和特异性高的探针药物(probe drugs)非常重要。第三，只有在充分建立表型和基因型相关的基础上，才可对受试人群进行大规模的有关基因型测定。
基于10个网页-相关网页
Cocktail probe drugs Cocktail探针药物法
Phenotype of CYP2D6 is indicated by probe drug, there are three major probe drugs having been used so far, namely debrisoquine, dextromethorphan and metoprolol. Phenotype can reflect the metabolism rate directly but cannot detect the genotype.
CYP2D6表型是用探针药物来判定的,可直观反映受试者对某些药物在体内代谢速度,但不能检测其基因型,且有些情况限制采用探针药物,存在价格昂贵、药物不良反应、伦理道德等问题。
参考来源 - 国人CYP2D6~*10基因多态性研究·2,447,543篇论文数据，部分数据来源于NoteExpress
METHOD:The probe drugs of drug metabolism, methods of phenotype and related factors were reviewed.
方法：综述近几年具遗传多态性代谢酶的探针药物、代谢分型方法以及影响因素。
To evaluate the activity of CYP450 in different groups, the metabolic rate of cocktail probe drugs was determined by HPLC.
通过高效液相色谱法检测探针药物的代谢率，评价各组CYP450酶的活性水平。
In the Present article, the characterization, substrates, probe drugs, factors affecting its activity, genetic polymorphism and the relation between CYP2D6 and several diseases were reviewed.
本文综述了CYP2D6的结构特点，底物，探针药物，影响其活性的因素，基因多态性以及它与疾病的关系。
应用推荐