The manufacturers for all four of these drugs will also be required to educate prescribers about the risks.

所有这四个药物的生产商都被要求来指导患者面对可能的风险。

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A boxed warning alerting prescribers to these reactions is included in the Product Information for clozapine.

氯氮平的产品说明中已经收列了这些信息，用以对医师们进行警告。

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Prescribers should be aware that potentially fatal myocarditis may develop early after the commencement of clozapine.

医师应该了解使用氯氮平的初期就能引起可能致命的心肌炎。

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Prescribers could also be given advice on prescribing medicines that are not licensed for children - so-called "off-label" prescribing.

BBC: NEWS | Health | Doctors get child medicines help

The drug makers, in turn, have to impose these things on prescribers (and then monitor whether the physicians comply).

FORBES: FDA Safety Regs Faulted for Lax Oversight

Opioid manufacturers must also provide prescribers and patients with information regarding the safe use of these drugs and the risks involved.

WHITEHOUSE: New Safety Measures for Opioid Medications