PHGDH catalyses the first step in the serine biosynthesis pathway, and breast cancer cells with high PHGDH expression have increased serine synthesis flux.

PHGDH催化丝氨酸生物合成途径的第一步，PHGDH高表达的乳腺癌细胞丝氨酸合成通量上升。

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In cells with high PHGDH expression, the serine synthesis pathway contributes approximately 50% of the total anaplerotic flux of glutamine into the TCA cycle.

在PHGDH高表达的细胞中，丝氨酸合成途径为三羧酸循环贡献了接近总量50%的谷氨酰胺回补通量。

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