Inhibitory effects of the flavonoid derivatives on P-glycoprotein (P-gp) -mediated drug efflux have attracted more and more interest of researchers.

黄酮类化合物对P糖蛋白外泵作用的抑制效果越来越引起人们的关注。

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The p-glycoprotein (P-gp) expression was determined by immunohistochemistry analysis.

免疫组化方法测定细胞表面P -糖蛋白表达。

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Platelet activation by P-selectin and monocyte cell surface P-selectin glycoprotein ligand - 1 combine to form PMA.

血小板活化后，通过P -选择素和单核细胞表面的P -选择素糖蛋白配基- 1结合形成PMA。

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But those with high P-glycoprotein were up to 20 times more resistant to doxorubicin and up to 300 times more resistant to vinblastine.

BBC: NEWS | Health | Cancer 'bouncers' keep drugs out

To see if the treatment could be effective, they grew balls of cancer cells in a laboratory, some with low amounts of P-glycoprotein, and others with high.

BBC: NEWS | Health | Cancer 'bouncers' keep drugs out

They knew a drug called XR9576 could block P-glycoprotein and sensitise individual cancer cells to chemotherapy, but they did not know if the drug would be successful against whole tumours, which can be very difficult to treat.

BBC: NEWS | Health | Cancer 'bouncers' keep drugs out