And when the United States and Russia are not able to work together on big issues, it's not good for either of our nations, nor is it good for the world.

如果美国和俄罗斯不能在重大问题上携手合作，将无益于我们两个国家乃至整个世界。

youdao

Until recently Treasury officials had believed that the big fiscal issues could not be resolved with the debt-ceiling clock running down.

直到最近，财政部官员还认为，重大财政问题无法在调整债务上限的最后期限一步步临近之时得到解决。

youdao

With the 'big bang' upgrade approach, I would not be able to rehearse or test the upgrade process and there was potential to be caught out by unknown issues.

按照这种“大爆炸式”的升级方法，我无法预演或测试升级过程，有可能遇到未知的问题。

youdao

"Overall,this will be a meeting about reaffirming the status quo, reaffirming the progress that's being made on lots of different issues, but not one with a big ambitious agenda."

VOA: standard.2010.05.17

As if that were not enough, the big issues are intrinsically tough.

ECONOMIST: India and Pakistan

The second time around Skype was fine, because we have excellent long term relationships and the issues were not as big.

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And the irony, I think, of our political climate right now is that, compared to other countries, the differences between the two major parties on most issues is not as big as it's represented.

WHITEHOUSE: President Obama Takes Questions at GOP House Issues Conference | The White House