Nolatrexed was synthesized by nitrification, bromination, reduction, condensation, oxidation by concentrated sulfuric acid, oxidation by hydrogen peroxide, acylation, cyclization, esterification, Ullmann reaction successfully in 2% total yields starting from toluene.
本文以甲苯为起始原料经过硝化、溴化、还原、缩合、浓硫酸氧化、双氧水氧化、酰化、酯化、成环、Ullmann反应成功合成了诺拉曲特,收率为2%。
参考来源 - 抗肿瘤药物诺拉曲特的合成·2,447,543篇论文数据,部分数据来源于NoteExpress
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