abstract:The malate-aspartate shuttle (sometimes also the malate shuttle) is a biochemical system for translocating electrons produced during glycolysis across the semipermeable inner membrane of the mitochondrion for oxidative phosphorylation in eukaryotes. These electrons enter the electron transport chain of the mitochondria via reduction equivalents to generate ATP.
Moreover, L-malateis a componentof malate-aspartateshuttle and is of importance in transporting NADH from cytosol to mitochondria for energy production.