Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis.

由于突变而引起的这些核心通路和调节过程的失调，是胰腺癌形成的主要特征性改变。

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Somatic mutation, a main biological phenomenon of citrus and other fruits, is often used for breeding as a major variation source. Spontaneous mutations often occur in citrus.

体细胞突变是柑橘等果树比较常见的生物学现象，也是品种选育，即芽变选种的主要变异来源。

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Conclusions No functional FANCA protein was found in these 3 cases of FA-A, and intragenic deletion, frame shift and splice site mutation were the major pathogenic mutations found in FANCA gene.

结论3例FA-A型患者均无功能性FANCA蛋白表达；基因缺失、移码突变和剪切位点突变是FANCA基因的主要失活方式。

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There's a major new mutation within the 2nd generation tablet and it brings significantly better battery life.

ENGADGET: Buying an iPad 2? Here's the rarer, more efficient specimen you need to (somehow) track down