... 分布容积、清除率、血药峰值浓度、血浆半衰期、药物剂 量的设计和优化 靶浓度(target concentration) 维持量(maintenance dose) 负荷量（loading dose）:首次剂量加大，然后再给予维 持剂量，使稳态治疗浓度提前产生。
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Methods:The open and self-controlled study was conducted in 47 patients with diagonized epilepsy. In addition to their original regimen maintained,they were also treated with topiramate in an initial dose of 50 mg*d-1,then increased to 100 mg*d-1 in 2 divided dose after 2 weeks,and with a maintenance dose of 200～400 mg*d-1 thereafter.
方法：进行开放性自身对照临床试验，对47例经临床和EEG确诊的癫痫患者在原有抗癫痫药物治疗不变的基础上，添加妥泰治疗，初始剂量为50mg*d-1，2周后为100mg*d-1，分2次服用，维持剂量200～400mg*d-1。
参考来源 - 添加托吡酯治疗癫痫的临床研究 Study of the efficacy of topiramate added to regimen for treatment of epilepsy·2,447,543篇论文数据，部分数据来源于NoteExpress
以上来源于: WordNet
In general, the initial dose depends on the volume of distribution, and maintenance doses depend on clearance.
一般而言，表观分布容积决定初始剂量，总清除率决定维持剂量。
Those assigned to clopidogrel received a 300-mg loading dose before PCI, followed by a maintenance dose of 75 mg daily.
被安排给予氯吡格雷的患者，在PCI前的负载量为300mg，之后的维持剂量为每天75mg。
By following these simple maintenance steps you will go a long-way towards extending the life of your housing and preventing a lethal dose of this deadly disease.
按照下面简单的维护步骤，你就可以延长你的防水壳寿命，同时避免这种病症。
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