This can lead to complications such as heart disease, stroke, kidney disease, blindness, and lower-limb amputation.

这些损伤会引起很多并发症，例如心脏病，中风，肾病，失明，甚至需要截断下肢。

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Patients are at risk for heart disease, kidney failure, limb amputation and other serious complications.

患者面临心脏疾病、肾衰竭、肢端坏死以及其它严重并发症的风险。

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Peripheral arterial disease frequently occurs, and is more likely to be conducive to critical limb ischaemia and amputation than in the absence of diabetes.

糖尿病患者与非糖尿病患者相比，外周动脉疾病更为常见，而且更易导致四肢重要动脉缺血和截肢。

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In future, therefore, it may be possible to pop a pill or have a shot to keep you both free of heart disease and lithe of limb.

ECONOMIST: Bugged by disease

They have the effects of heart disease, or they break a limb, and they have no way of paying for it.

NPR: For Many, Health Care Reform Can't Wait

In the U.S., a pharmaceutical company that goes out on a limb and develops a new treatment for a disease gets an exclusive right to market that compound for more than a decade.

FORBES: Magazine Article