"I think that the Americans want to improve their relations with Syria to weaken Iran and to further isolate it in the region, so I don't think the Americans need Syria as a mediator with Iran, because that would improve relations between Tehran and Damascus,"

VOA: standard.2009.03.18

Whereas if the Iranian government continues down its current path, it will only further isolate Iran.

WHITEHOUSE: Statement by President Obama on Nowruz

And the interests that we have undertaken to further isolate Iran with our international partners we believe will continue to pressure the regime and drive it to the conclusion that it needs to get right with the world.

WHITEHOUSE: Press Briefing