Despite high mutation detection rate, many HBOC cases remain without identified cause.

尽管有很高的突变检出率，但是许多HBOC仍然没有可识别的原因。

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They are particularly vulnerable to high mutation rates, which undermine genetic vigour.

恪守无性清律的物种，在基因高突变率下特别脆弱，大量的突变使原有的遗传基因大伤元气。

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Error catastrophe occurs when high mutation rates give rise to so many deleterious mutations that they make the population go extinct.

当高突变率引发众多能导致种群灭绝的有害突变时，错误突变便出现了。

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In the trial, which included 55 patients, tumors dramatically shrank in 9 of 16 very advanced patients with the gene mutation who got high doses--a better response rate than doctors have remembered seeing in a trial for advanced melanoma.

FORBES: American Society of Clinical Oncology

By contrast, Japanese patients with another gene mutation were found to have high HDL but no evidence of benefit.

FORBES: Magazine Article