He abandoned himself to despair.

他陷入绝望。

《牛津词典》

I despair of him; he can't keep a job for more than six months.

我对他都绝望了，他做任何工作都超不过半年。

《牛津词典》

"Oh, I despair sometimes," he says in mock sorrow.

“哦，我有时会绝望。”他假装悲伤地说。

《柯林斯英汉双解大词典》

He said many people are feeling doubt, even despair,about the future.

VOA: standard.2010.01.17

They were wandering in the forests and he was in despair, having lost everything.

他们在森林里流浪,那勒陷入绝望,他失去了一切

耶鲁公开课 - 金融市场课程节选

Mind you, he ascribes to authorial intention the most amazingly outrageous things that other critics threw up their hands in despair about, but nevertheless it is for him always still an appeal to authorial intention.

他认为写作意图,十分重要,但是被其他批评家忽视了，但是写作意图,十分吸引他。

耶鲁公开课 - 文学理论导论课程节选

For some reason, however, he was in despair when he returned home that night.

NPR: Literature and Lullabies from the 'Axis of Evil'

Sometimes he seemed to despair (he wrote a book about overcoming depression) but he never gave up.

ECONOMIST: Julian Simon

Warnock declined to speak about his own future after the game, wisely given the acute sense of despair he would have been feeling.

BBC: Tevez delivers final twist