Aging heredity and genic mutation are the definite main pathogenic factors; in addition the decrease of neurotransmitter, inflammation, stress, etc are the possible pathogenic factors.
增龄、遗传及基因突变为其明确的致病原因，此外，代谢异常、神经递质减少，炎症及应激等都为其可能的致病原因。
参考来源 - “补肾益智方”改善老年痴呆长时程增强现象的实验研究·2,447,543篇论文数据，部分数据来源于NoteExpress
Bovine leukocyte adhesion deficiency (BLAD) is autosomal recessive disease. The pathogeny of BLAD is genic mutation of CD18-integrins on the leukocyte.
牛白细胞粘附缺陷病(BLAD)是一种常染色体单基因隐性遗传疾病，病因为白细胞表面整合素cd 18亚单位基因突变所致。
The reason of congenital cataract is multiple, about one third is related to genetic factor and genic mutation, one third is environmental factor, the rest is unknown.
先天性白内障的病因复杂多样，约三分之一与遗传因素和基因突变有关，三分之一与环境因素有关，三分之一病因不明。
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