These gene mutation distributing in all over the whole coding section of ATM gene. Every Exon exist the gene mutated site and no obvious hot mutated site be discovered.

这些突变分布于atm基因整个编码区，每个外显子都存在基因变异位点，没有发现明显的突变热点。

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For example, the hereditary hemochromatosis mutation protects carriers from iron-deficiency because the mutated gene allows increased efficiency of iron absorption.

例如，因为突变的基因可以提高铁的吸收效率，所以遗传性血色素沉着病突变可以保护带菌者不缺铁。

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We have to do in-vitro cell culture experiments first, prove it in an animal model, and then develop a molecule or protein which will affect the mutated gene product.

我们首先得做一个体外细胞培养实验，在动物模型中证明它的存在，然后开发出一种能影响突变基因产物的分子或蛋白质。

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But keep in mind that the scientists say this mutated gene may be rare.

VOA: special.2009.08.26

If one gene is mutated, a duplicate gene may function in its place.

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Genentech's breast cancer drug Herceptin works only in women whose cancer has a particular mutated gene.

FORBES: Why Cancer Drugs Need Genetic Testing

At this point, a woman can undergo the more complex genetic test to confirm the presence of the mutated gene.

BBC: DNA spiral