abstract:García Jofre de Loaísa (1490 – 20 July 1526) was a 16th-century Spanish explorer ordered by King Charles I of Spain to command an expedition to Asia, known as the Loaísa expedition, which in 1525 was sent by the western route to colonize the Spice Islands in the East Indies, thus crossing the Atlantic and Pacific oceans. More than 450 men were aboard, including different kinds of trades and administrative staff, intended to establish a permanent Spanish settlements in the Spanish East Indies.