Methods Apraclonidine was synthesized from P-Nitraniline by reaction with reduction, adding protection group, formylation, chlorination, cyclization, off-protecting group.
方法采用对硝基苯胺为原料，经还原、加保护基、甲酰化、氯化、环合、脱保护基六步反应法可进行化学合成。
Also the optimum reaction conditions including formylation, method and reaction time of cyclization were studied to enhance the yield. In the end, their fluorescence spectrum are analyzed.
同时对反应过程中的甲酰化、环合方法、反应时间进行了探讨，优化了反应条件，提高了产率，并对化合物的荧光光谱进行了分析。
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