Animals genetically altered in a way that limited their synthesis of ceramide didn't become insulin resistant when taking the drug as normal animals did.

基因修改过不能合成神经酰胺的动物在吃药的情况下也和正常动物一样，不会产生胰岛素抵抗。

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Moreover, the researchers show, a treatment that blocks ceramide's synthesis markedly improves insulin response and prevents the onset of diabetes in obese rodents.

此外，研究者表示，阻断神经酰胺的合成可以显著的改善胰岛素反应并且可以阻止肥胖啮齿类动物产生糖尿病。

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Exposure of islet cells to high concentration of glucose, dexamethosone and palmitate can reduce the expression of PDX-1, therefore affects the insulin synthesis of islet cells.

高浓度的葡萄糖、糖皮质激素、脂肪酸可抑制PDX-1蛋白的表达，从而抑制胰岛细胞的胰岛素分泌功能。

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