Method: The rat model of DN was constructed by intraperitoneally injected streptozocin(STZ), and the body weight, blood glucose, endothelin(ET) and nitric oxide(NO) were measured.

方法：链尿佐菌素（STZ）腹腔注射诱导建立DN大鼠模型，检测体重、血糖、内皮素（ET）和一氧化氮（NO）的变化。

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Rats in DN group and TWP group were given streptozocin (STZ) by intraperitoneal injection to establish animal model of diabetes.

糖尿病组与TWP治疗组大鼠分别给予链脲菌素(STZ)一次性腹腔注射建立糖尿病大鼠模型。

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