Poor database storage design can have a significant negative impact on a database server.

糟糕的数据库存储设计对数据库服务器有极大的负面影响。

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Both trends put together would mean that aging will have a significant negative impact on global growth, " Duggar said."

两大趋势叠加意味着老龄化将对全球增长产生显著负面影响。

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We recognize the significant negative impact of illicit financial flows on our economies and we continue to take forward the work of the G20 on this theme.

我们认识到非法资金流动对各国经济都会产生巨大负面影响，并将继续推进G20在这方面的工作。

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This is likely to have a significant negative impact on its year-over-year and sequential revenue figures.

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But as mining slows, it could have a significant negative impact on the Australian economy, Eliseo said.

FORBES: INTERVIEW: Cut In Australian Interest Rates May Push Aussies Toward Gold --Economist

The consequences of these changes are severe and have had a significant negative impact on private companies and their investors.

FORBES: The Case For Private Company Stock Marketplaces