However, we have documented several significant issues that need to be addressed when using placebo product to validate cleaning processes.

然而，我们的文件可以证明在使用无效药验证清洗过程时需要阐明的几个重要问题。

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This change leads to several issues, the most significant of which is changing the IP address of your domain name.

这个变化会导致几个问题，其中最重要的是修改域名的IP地址。

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Due to corrosion issues, several cities worldwide have had to invest significant funds into repairing Bridges, as the landmarks have become safety hazards.

由于腐蚀因素，世界上许多城市将投入大量资金对桥梁进行维修，因为这些标志性建筑已经变成安全隐患。

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Several major political issues are still looming over Wall Street: the lack of significant, sustainable job creation through incentives for starting or expanding small businesses, the housing inventory glut, overspending and the national debt, and the Dodd-Frank Bill (only 5% of which has been implemented to date).

FORBES: Is The Bull Market Topping?