Objective To evaluate the efficacy and toxicity of irinotecan combined with nedaplatin in second-line therapy of small-cell lung cancer.

目的观察伊立替康联合奈达铂二线治疗小细胞肺癌的疗效及毒副反应。

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One caveat with this trial, as with any study of this kind, is that it does not take into account the possible impact of second-line therapy.

需要提醒的是，与任何一个同类的研究一样，此试验未考虑二线治疗的可能影响。

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It can be used in the patients with recurrent ovarian cancer as a second or third line therapy.

尤其是对复发病人仍有效，可做为复发卵巢癌的二线或三线化疗。

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"Our study would strongly suggest that it is not beneficial to do it as front-line treatment but to reserve it as second-line or salvage therapy, " said study leader Dr. Mark Gilbert of the University of Texas MD Anderson Cancer Center in Houston.

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"What we do not agree with is that it should be used as a second- or third-line therapy, " says Enrico Veltri, the Schering-Plough vice-president in charge of heart disease drugs.

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