Combination is the soul of formulae. In general, compatibility in compound formulae aims at synergy and reduction of toxicity.
配伍是方剂的灵魂,复方中的配伍组合从总体上都实现了趋利避害,从而确保方剂增效减毒的总体目标。
Use of single-ligand formulations led to a reduction in viability (increased toxicity) not only in target KB cells but also in off-target cells with the targeted receptor available.
使用单配体配方不仅会导致靶向KB细胞活性的减少(增强了毒性),同时也使含有靶向受体的非靶向细胞活性降低。
Selective targeting of drugs to kidneys may enable an increased renal effectiveness combined with a reduction of extrarenal toxicity.
将药物靶向到肾脏不仅能降低肾外毒性,而且能增加药物在肾脏的作用效果。
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