Heat shock protein(HSP) shows both biological effects of up-regulation and down-regulation on apoptosis. Especially the suppressive effects on apoptosis provide a new path to treat various diseases.

热休克蛋白（HSP）对细胞凋亡有双向调控作用，尤其是其抗细胞凋亡的作用为临床多种疾病的治疗开辟了新的途径。

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CONCLUSION: the up-regulation of the expression of hippocampal GAD67 protein in rats with temporal lobe epilepsy is one of the mechanisms of organic endogenous anti-epilepsy after seizures.

结论：颞叶癫痫大鼠海马gad67蛋白表达的增高是癫痫发生后机体的内源性抗痫机制之一。

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Furthermore, androgen up-regulation of intracellular ar protein was partially inhibited (50%) by nonsteroidal androgen antagonist, flutamide.

雄激素拮抗剂氟他胺也能够部分抑制(5 0 %)睾酮对细胞内AR蛋白水平的上调作用。

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