You may be physically and mentally exhausted after a long flight.

长途飞行后你可能身心都很疲惫。

《柯林斯英汉双解大词典》

Many days, my technicians and I are physically and mentally exhausted by 2:00 PM.

在好些日子里，我和我的技术伙伴们都要工作到下午2点钟，身心俱疲。

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We can always feel that physically and mentally exhausted, never get anything right.

我们总会感到身心疲惫，事事不顺。

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We are very often too tired, too busy, too exhausted mentally and physically to stand up and shout enough is enough, and please help.

BBC: Disability care: Your stories