胰腺十二指肠同原异形盒(Pancreatic DuodenumHomeobox-1,PDX-1)是胰岛素基因转录的主要调节因子,它对于胰腺的发育、胰岛β细胞基因的表达、胰岛β细胞分化及维持β细胞的...
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Objective to study whether the PDX-1 protein has antiapoptosis effects induced by palmitic acid on rat islet of Langerhans.
目的探讨PD X - 1蛋白对棕榈酸诱导的大鼠胰岛凋亡的保护作用。
Objective to construct eukaryotic expression vector of human pancreatic duodenal homeobox 1 (PDX-1) gene, and to detect its expression in NIH3T3 cell lines.
目的构建人胰十二指肠同源盒(PD X - 1)基因的真核表达载体，观察其在NIH3T3细胞中的表达。
Exposure of islet cells to high concentration of glucose, dexamethosone and palmitate can reduce the expression of PDX-1, therefore affects the insulin synthesis of islet cells.
高浓度的葡萄糖、糖皮质激素、脂肪酸可抑制PDX-1蛋白的表达，从而抑制胰岛细胞的胰岛素分泌功能。
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