Mutation P53 gene protein 突变型P53基因蛋白
Objective: To analyse the significance and relationship between p53 gene mutation and the expression of mutant type p53 gene protein in the laryngeal carcinomas.
目的：探讨喉癌P 53基因突变与突变性P 53基因蛋白表达之间的相互关系及意义。
They found that the p53 gene makes not only the well-established p53 protein, but also an alternative "control switch" variation of the p53 protein - known as an isoform.
他们发现p53基因不仅产生大家熟知的p53蛋白质，同时还产生一种p53蛋白质变换“控制开关”的变种——对碘氧基苯甲醚。
The protein(P53) encoded by mutant p53 gene (mtp53) not only losses these functions, but also make cell malignant transformation.
突变型p53基因的编码蛋白不但丧失上述功能，甚至出现了促使细胞癌变的作用。
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