This article focuses on the pathogenesis of chronic wound and introduces progress in various kinds of treatment, such as skin substitute, growth factors, negative pressure treatment, etc.
本文着重讨论了难愈创面的发生机制，并介绍了各种治疗手段如皮肤替代物、 生长因子、创面负压治疗技术等的应用进展。
Stannard et al. randomized sixty-two severe open fractures to treatment with negative-pressure wound therapy or sterile moist saline solution dressings until ultimate closure or coverage7.
Stannard等随机对比62例应用伤口负压疗法或无菌湿盐水敷料治疗的严重开放性骨折，直至伤口最终闭合或被组织覆盖7。
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