In contrast, bioavailability differences are important for a drug with a relatively narrow therapeutic index.
相反，对于治疗指数相对狭窄的药物来说，生物利用度的差异就很重要。
Most anticancer drugs are characterized by a narrow therapeutic index, wide inter patient variability of pharmacokinetic parameters and high toxicity.
许多抗肿瘤药具有治疗指数低的特征，其药代动力学在病人个体间存在较大的差异，而且具有较高毒性。
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