Objective: To analyse the significance and relationship between p53 gene mutation and the expression of mutant type p53 gene protein in the laryngeal carcinomas.
目的:探讨喉癌P 53基因突变与突变性P 53基因蛋白表达之间的相互关系及意义。
Methods:Immunohistochemistry and PCR-SSCP were used to detect the expression of P53 protein and p53 gene mutation in 32 cases of TSCC and 10 cases of tongue leukoplakia.
方法:应用免疫组织化学和聚合酶链反应—单链构象多态性分析(PCR-SSCP)检测10例舌白斑和32例舌癌,并结合临床资料进行分析。
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