To live in despair is a mark of great endurance, whereas to grow dull and stupid after a great unhappiness is a mark of deficiency.

生活在绝望之中象征着巨大的忍耐力，而在经历巨大的痛苦之后变得迟钝愚蠢则是缺乏忍耐力的表现。

youdao

I to the world completely despair! Even small sandu like you can live in this world!

我对这个世界彻底的绝望了！连你这样的小三都能活在这个世界上！

youdao

In the second sense, the word describes a major mood disorder of intense sadness, despair, paralysis, etc. that does disrupt your capacity to live a normal life.

从第二层意思来看，这个词描述的是一个极度悲伤、绝望、瘫痪等等的重大情绪紊乱。这个时候，干扰了人们正常生活的能力。

youdao

After his two losers, Jack (Peter Beard) and Leo (Martin Greenbaum), spend seven years courting the same woman, Vera (each has his own version of her, played by different actresses), she runs off with a third man, and her jilted suitors head for the wilderness in raucous despair to live out a survivalist fantasy that joins Mark Twain and Ernest Hemingway to Charlie Chaplin, W. C.

NEWYORKER: Hallelujah the Hills