本研究分三个部分探讨中波紫外线辐射对人皮肤成纤维细胞(human skin fibroblasts,HSFs)表达基质金属蛋白酶-1 ( matrix metalloproteinase-1 , MMP-1 )...
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ConclusionUVA can injure the proliferation activity of human skin fibroblasts, it might be related to the up-regulation of iNOS gene expression and the over-secretion of NO induced by UVA.
结论UVA损伤原代培养的人皮肤成纤维细胞可能与其诱导iNOS基因的表达和NO的分泌有关。
参考来源 - UVA致人成纤维细胞和角质形成细胞损伤机制及白藜芦醇的光保护作用MethodsCultured human skin fibroblasts and treated with different dose of intense pulse light radiation. By culturing 24 hours analyzed cell cycle with flow cytometr（FCM）, the cell proliferation activity was measured by MTT assay.
方法：培养人皮肤成纤维细胞，应用MTT比色法、免疫组织化学的方法和流式细胞仪（FCN）分析技术，观察皮肤成纤维细胞经不同能量的强脉冲光照射后细胞的生长活力、细胞增殖能力以及细胞周期变化。
参考来源 - 强脉冲光对成纤维细胞增殖与周期的影响—《中国美容医学》—2007年第10期—龙源期刊网·2,447,543篇论文数据，部分数据来源于NoteExpress
Conclusion GMCSF can up-regulate the expression of VEGF in human skin fibroblasts, and ERK pathway plays an important role in this process.
结论GMCSF可促进人皮肤成纤维细胞VEGF表达，ERK通路在此过程中发挥重要作用。
Results The morphological characteristics of three kinds of cells were accord with those of vascular endothelial cells and smooth muscle cells and human skin fibroblasts.
结果培养细胞符合血管内皮细胞、血管平滑肌细胞及成纤维细胞的各有形态特征。
Conclusion Senescence of human skin fibroblasts can be induced by UVB irradiation, and the mechanism may relate to the decrease of collagen synthesis and increase of collagen degradation.
结论U VB照射能诱导人皮肤成纤维细胞发生衰老，其机制可能与细胞胶原合成减少而降解增加有关。
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