OBJECTIVE To investigate the effect of drug concentration, drug structure of fluoroquinolones on the resistant gene of Escherichia coli mutants selected in the mutant selection window (MSW).
目的：研究不同药物浓度、不同化学结构的氟喹诺酮类药物对突变选择窗(MSW)内筛选的大肠埃希菌耐药突变体的靶位耐药基因的影响。
Objective To evaluate the effect of craniotomy on the CSF drug concentration by measuring drug concentration in blood, in subcutaneous transudation and in CSF.
目的通过测定开颅术后周围静脉血、皮下引流液及脑脊液中药物浓度，来评价开颅手术对脑脊液药物浓度的影响。
Conclusion Tumor metastasis status of rectal cancer lymph nodes exerts insignificant effect on drug concentration for LC and RERC.
结论直肠癌淋巴结转移状态对RERC和LC淋巴结内药物浓度聚集无明显影响。
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