Objective:To evaluate the feasibility of transcatheter closure of patent foramen ovale(PFO)to prevent paradoxical embolism with Amplatzer occluder device.

目的：经导管封堵卵圆孔未闭（PFO）预防脑的矛盾栓塞并评价其疗效。

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Does Closure of Patent Foramen Ovale as a Treatment for Migraine with Aura?

孔未闭的封堵治疗是先兆性偏头痛的选择吗？

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The PC T rial (Clinical Trial Comparing Percutaneous Closure of Patent Foramen Ovale Using the Amplatzer PFO Occluder with Medical Treatment in Patients with Cryptogenic Embolism) randomized 414 patients with PFO who had had an ischemic stroke, TIA, or a peripheral thromboembolic event to either medical therapy or PFO closure with the Amplatzer PFO Occluder.

FORBES: Controversial PFO Closure Trials Published In NEJM

Some of them may interpret the data as supporting closure of a patent foramen ovale as a viable therapeutic option, even while conceding the failure of trials to show the superiority of closure over medical therapy.

FORBES: Controversial PFO Closure Trials Published In NEJM