AIM: TO obtain high level expression of recombinant human truncated osteoprotegerin (TOPG) with higher bioactivity in CHO-DHFR-cells.

实现其在CHO - DHFR -细胞中的高效表达，获取生物活性较高的重组蛋白。

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CONCLUSION: MTX induced-increase of recombinant antibody production in CHO cells can be increased by weakening the expression of DHFR gene.

结论：弱化表达载体中DHFR的表达，可提高MTX对工程抗体表达的增加效果。

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