Objective To investigate the memory amelioration of the AD model rat after a single or combined transplantation of the neural stem cells(NSCs) modified with gene of NGF or GDNF.
目的观察NGF GDNF基因修饰神经干细胞（NSC）单独和联合移植对AD模型鼠的学习记忆改善作用。
Objective: to observe the protective effect of Panax notoginseng saponins (PNS) against pathological lesion of cholinergic neuron in rat model with Alzheimer's disease (AD).
目的：观察三七总皂苷(PNS)对老年性痴呆(AD)大鼠模型大脑胆碱能神经病理损害的保护作用。
Conclusion: the level of ERK increased in hippocampus of rat model of AD, which showed changes of signal transduction route in the early phase.
结论：穹窿海马伞切断ad大鼠海马erk升高，说明erk信号转导途径在AD发病早期有改变。
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