Many factors impaired aveole epithelium and capillary endothelium cells,which lead to the activation of macrophage,the infiltration of mononuclear cell and neutrophil,inflammatory cell and its releasing factors mediate the the impair of the lung.
各种损伤因素损伤肺泡上皮细胞和毛细血管内皮细胞,引起巨噬细胞活化,单核细胞,中性粒细胞等炎症细胞浸润,炎症细胞及其释放的细胞因子介导了早期的肺损伤。
参考来源 - 类风湿关节炎患者外周血单个核细胞中VEGFmRNA的表达及与间质性肺疾病的关系·2,447,543篇论文数据，部分数据来源于NoteExpress
Objective To discuss the role of alveolar macrophage activation in rats with acute necrotizing pancreatitis (ANP) associated with lung injury.
目的探讨肺泡巨噬细胞活化在急性坏死性胰腺炎(ANP)肺损伤中的作用。
Different pathways of macrophage activation result in cells with widely diverse effects on inflammation and fibrosis.
各种途径的巨噬细胞激活后引起细胞对炎症和纤维化的不同应答。
Result: Rats in the model group have lower levels of NPY in seahorse, ACTH and CORT in blood , and spleen macrophage accrementition and activation (P<0.01).
结果：模型组大鼠海马组织中NPY的释放减少，血浆中ACTH和血清中CORT含量显著降低，脾脏巨噬细胞数目显著增加（P<0.01）。
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